Description
Product Characteristics:
The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. MPP1 (M-phase phosphoprotein 1), also known as KIF20B (kinesin family member 20B), MPHOSPH1 or KRMP1, is a 1,820 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one kinesin-motor domain. Expressed in kidney, brain, testis and ovary, MPP1 functions as a plus-end directed motor enzyme that interacts with Pin1 and is required for the completion of cytokinesis. MPP1, which exists as multiple alternatively spliced isoforms termed 1-5, is subject to post-translational phosphorylation, probably by ATM or ATR.
Synonyms: palmitoylated 1, 55 kDa erythrocyte membrane protein, AAG 12, AAG12, Aging associated gene 12, DXS552, DXS552E, EM55_HUMAN, EMP 55, EMP55, EMP-55, Erythrocyte membrane protein p55, Membrane protein, Membrane protein palmitoylated 1 55 kDa, Membrane protein palmitoylated 1, Membrane protein, palmitoylated 1, 55 kDa, Migration related gene 1, MPP 1, MPP1, MRG 1, MRG1, p55 antibody Palmitoylated erythrocyte membrane protein, Palmitoylated membrane protein 1, PEMP.
Target Information: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]